Hyperperfusion due to the increased blood pressure can also cause kidney damage and failure that results in a vicious cycle (hyperpefusion destroys nephrons, remaining nephrons are even more perfused to compensate for nephron loss, which destroys more nephrons, which hyperperfuses more, and on and on). Angiotensin II and aldosterone are also important in stimulating the cardiac remodeling that leads to heart failure.
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Renin-Angiotensin -Aldosterone
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