It's because in visceral leshmaniasis the amastigotes of the parasite infect the macrophages. And subsequently,,the immune response relies on the activation of the macrophages thru various inflammatory cytokines((inf,,IL12)) to control de infection within them,,increased cytokines disrupts hypothal-pit-adrenal axis wit incresd CRH & incresd ACTH,,incresd MSH as part of the byproduct of POMC,,nd that wud lead to hyperpigmentation,,
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Leishmaniasis
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